Effects of <i>APOE</i> genotype on amyloid PET positivity according to cognitive status and ethnicity

Background Among the various risk factors for Alzheimer disease (AD), apolipoprotein E (APOE) genotype ε4 is known to be a strong factor. On other hand, ε2 have protective effect. It not yet clear how amyloid positivity according APOE differs by diagnostic criteria. Also, there were no studies showing ethnic difference in effects of on amyloid-beta (Aβ) between American and Asian. The aim this study was investigate Aβ (Aβ+) genotypes ethnicity cognition. Method We recruited 4,203 Korean subjects from multi-centers South Korea 1,069 Alzheimer’s Disease Neuroimaging Initiative database. All underwent neuropsychological tests, PET (FMM/FBB/AV45) scans. Subjects with ε2/ε4 excluded due opposing alleles. degree influence each factor analyzed logistic regression. Result frequency Aβ+ normal cognition (NC) group higher ADNI than (p <0.001). Amnestic mild cognitive impairment AD dementia (ADD) groups showed groups. Relative ε3/ε3 group, carriers frequent regardless status (Figure). less ADD but NC relative group. Conclusion Our findings suggested that differences European Korean. These will helpful predicting intervention ethnicity.